Optochin-resistant <i>Streptococcus pneumoniae</i>
نویسندگان
چکیده
منابع مشابه
Optochin-resistant Streptococcus pneumoniae.
Streptococcus pneumoniae (pneumococcus) remains a major cause of mortality and morbidity at the extremes of age. With increasing antibiotic resistance, its accurate early identification is important for initial management [1]. Its identification in clinical laboratories relies on colony morphology, α-haemolysis on blood agar, and optochin susceptibility. The bile solubility test, although simpl...
متن کاملComparison of five genotypic techniques for identification of optochin-resistant pneumococcus-like isolates.
Three PCR techniques (amplification of the psaA, ply, and lytA genes) and a commercial kit (AccuProbe [GenProbe, San Diego, Calif.], based on hybridization with the 16S rRNA gene), all four of which claimed to be specific for Streptococcus pneumoniae, were used to identify 49 alpha-hemolytic streptococcal isolates suspected of being pneumococci. The definite phenotypic identification of these o...
متن کاملCharacterization of in vitro-generated and clinical optochin-resistant strains of Streptococcus pneumoniae isolated from Argentina.
Optochin susceptibility is a key test used for pneumococcal diagnosis, but optochin-resistant (Opt(r)) pneumococci have been reported in the last 2 decades. In this work, we characterized eight Opt(r) clinical strains which presented a new mutation, G47V, a predominant A49S mutation (recently reported in Brazil) and A49T. These mutations were found in the c subunit of the F(0)F(1) ATPase encode...
متن کاملOptochin in the identification of str. pneumoniae.
In 1911 Morgenroth and Levy showed that mice could be protected against pneumococcal infection with "optochin " (ethylhydrocupreine hydrochloride). The clinical use of this agent was soon abandoned as it was found to be toxic and, in doses which could be tolerated, did not influence the course of lobar pneumonia (Moore and Chesney, 1917; White, 1938). Subsequent in vitro studies showed that of ...
متن کاملAlteration in bacterial morphology by optochin and quinine hydrochlorides.
Incubation of washed bacterial and ribosomal suspensions with optochin or quinine hydrochloride caused an increase in the turbidity of the suspensions and the appearance of electron-dense cytoplasmic aggregates in the treated cells. These effects were more pronounced with optochin hydrochloride than with quinine hydrochloride, and they did not correlate with the relative sensitivities of differ...
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ژورنال
عنوان ژورنال: Ceylon Medical Journal
سال: 2011
ISSN: 2386-1274,0009-0875
DOI: 10.4038/cmj.v56i2.3123